A major question which remains unanswered in the study of puberty is why gonadotrophin secretion decreases in mid childhood, with or without the presence of functioning gonads. Factors that trigger the onset of puberty are likewise unknown, although the onset of puberty can be stimulated or delayed by certain destructive lesions: for example, anterior hypothalamic tumours or injuries can advance the onset of puberty, while posterior hypothalamic injuries or tumours can delay the onset of puberty or eliminate it.
Thus, it appears that the onset of puberty is caused by a decrease in inhibition of the central nervous system ΓÇô an inhibition that can be destroyed by certain disorders, leading to the early onset of puberty.
See later:
ΓÇó Hormonal Levels in Turner's Syndrome in Puberty
